The Recomp Stack.

Body recomposition protocol combining GH optimization, targeted lipolysis, and metabolic enhancement for simultaneous fat loss and lean mass preservation.

Fat LossLean MassGH OptimizationMetabolic
The Recomp Stack targets the dual challenge of body recomposition: reducing adipose tissue while preserving or building lean mass. This requires shifting the caloric partition away from fat storage and toward muscle maintenance. The protocol combines three compounds with non-overlapping mechanisms: CJC-1295/Ipamorelin stimulates pulsatile growth hormone release to support lean mass and mobilize fatty acids, AOD-9604 provides targeted lipolytic activity through a GH-receptor-independent pathway, and MOTS-C activates AMPK to enhance metabolic flexibility and cellular energy expenditure. Each compound targets a distinct node in the metabolic network, creating a synergistic framework where the whole exceeds the sum of parts.
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Stack Components.

Cat 1 / Cat 2 GH Axis Optimizer

CJC-1295/Ipamorelin.

Modified growth hormone-releasing hormone analog (CJC-1295) paired with a selective growth hormone secretagogue (ipamorelin). Stimulates natural, pulsatile GH release without disrupting other pituitary hormones.
In this stack: Serves as the foundation by elevating GH and downstream IGF-1. This supports protein synthesis, nitrogen retention, and lipolysis through the natural GH axis. The pulsatile release pattern preserves feedback sensitivity, avoiding the desensitization seen with continuous GH exposure.
Category 1 Targeted Lipolysis Agent

AOD-9604.

Modified fragment (amino acids 176-191) of the growth hormone molecule that retains lipolytic activity without growth-promoting or diabetogenic effects.
In this stack: Provides direct lipolytic signaling through a GH-receptor-independent mechanism. AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipose tissue without the insulin resistance, fluid retention, or growth effects of full-length GH. This isolates the fat-loss component of GH action.
Category 1 Metabolic Amplifier

MOTS-C.

Mitochondrial-derived peptide that activates AMPK, the master metabolic sensor, enhancing glucose uptake, fatty acid oxidation, and metabolic flexibility.
In this stack: Adds a metabolic dimension by activating AMPK-driven energy expenditure. This increases the caloric deficit on the expenditure side rather than the intake side, complementing the lipolytic effects of AOD-9604 and the anabolic protection of CJC-1295/Ipamorelin. Acts as a cellular exercise mimetic.

Why These Compounds Work Together

The three compounds create a triangulated metabolic intervention. CJC-1295/Ipamorelin provides the hormonal environment for lean mass preservation (elevated GH/IGF-1 supports protein synthesis and nitrogen retention) while mobilizing fatty acids. AOD-9604 amplifies the lipolytic signal through an independent pathway, ensuring fat mobilization continues even if GH receptor sensitivity fluctuates. MOTS-C drives the oxidation of mobilized fatty acids through AMPK-activated mitochondrial pathways, preventing re-esterification and storage. The net effect is a caloric partition that favors muscle preservation while accelerating fat oxidation, the definition of body recomposition.
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Safety Considerations.

Each compound in this stack has a distinct safety profile. CJC-1295/Ipamorelin is among the better-tolerated GH secretagogues, with main concerns being water retention, joint stiffness, and elevated IGF-1. AOD-9604 has shown favorable safety in clinical trials (it received GRAS status in Australia for food applications). MOTS-C is an endogenous peptide with limited formal safety data. Combining multiple compounds increases the complexity of potential interactions. All three compounds are research-stage for body recomposition applications and lack combined-use clinical trial data. IGF-1 levels should be monitored with any GH-elevating protocol.
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Source These Compounds.

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Frequently Asked Questions.

Research Disclaimer: Content on PowerPeptides.co is for informational and research purposes only. It is not medical advice. Peptides discussed are research compounds unless explicitly noted as FDA-approved. Always consult a licensed healthcare provider before beginning any peptide protocol. Full Disclaimer | Affiliate Disclosure